AVIPRO SALMONELLA DUO

The only live dual-strain vaccine containing S.Enteritidis and S.Typhimurium.

Providing superior, direct protection1 against both regulated Salmonella strains in layers2


Optimal Salmonella protection is a priority

Salmonella is costly (a Salmonella outbreak among free-range birds in the UK can cost producers up to £17 per bird3) and concerning (Salmonellosis represents half of all global foodborne outbreaks requiring hospitalisation4 and causes around 59,000 deaths each year5).


Robust control of Salmonella requires a holistic and integrated approach, with vaccination at its core:

» Excellent biosecurity and hygiene

» Effective vaccination strategy

» Good monitoring and flock management

BOTH is best for superior, direct protection

Avipro vaccine MOA


Better protection:

When challenged with a field strain of S.Typhimurium (at much higher levels than would be seen in the field via natural infection), birds vaccinated with AviPro Salmonella Duo had significantly lower numbers of field strains in the caeca and spleen compared with a live S.Enteritidis vaccine1

Reduced shedding into the laying period:

Some live vaccines have shedding patterns that can extend well into the production period, potentially exposing the table egg to vaccine residues9. AviPro vaccines provide the efficacy of live vaccines but are not shed by vaccinated birds during the production period.

Avipro rearing production


Improved egg safety:

Egg duo


AviPro Salmonella Duo is the only vaccine that protects eggs from internal contamination with S.Enteritidis6a.

Avipro Salmonella Duo brochure

Avipro Salmonella Duo brochure

Log in to download the Avipro Salmonella Duo brochure (pdf)

Watch our mode of action video to understand more about Salmonella works

  1. Koerich, P. and Doblies, D. Comparison of the efficacy of a live bivalent Salmonella vaccine with a monovalent vaccine against a challenge with a Salmonella Typhimurium field strain. IPPE International Production & Processing EXPO, Altanta (2023).
  2. UK National Control Programme for Salmonella in Layers (gallus gallus): ‘Laying hens and flocks: poultry testing for salmonella’ government guidance. https://www.gov.uk/guidance/ salmonella-get-your-egg-laying-hens-tested 
  3. Elanco Market Research Cost of a Salmonella Outbreak 2023 Free Range 320000 - Scrutton Bland 
  4. EFSA Journal 2021. The European Union One Health 2019 Zoonoses Report. EFSA Journal;19(2):6406 
  5. WHO Estimates of the Global Burden of Foodborne Diseases 2007-2015. https://apps.who.int/iris/bitstream/ handle/10665/199350/9789241565165_eng.pdf. 
  6. AviPro Salmonella Duo Summary of Product Characteristics b compared to 2 other SE live vaccines.
  7. REF-03435 — Development of a third generation vaccine to prevent Salmonella infections Salmonella infections. 
  8. Barrow, P.A., et al. Faecal shedding and intestinal colonization of Salmonella enterica in in-bred chickens: the effect of host-genetic background. Epidemiology & Infection 132.1 (2004): 117-126. 
  9. Koerich P; Mueller- Doblies D. (2023) Evaluating the shedding pattern of two live S. Enteritidis vaccines in laying hens during the early phase of production. Poster presented at IPPE International Production & Processing EXPO- Atlanta Jan 2023 
  10. Gantois I, Ducatelle R, et al. Mechanisms of egg contamination by Salmonella Enteritidis. FEMS Microbiology Reviews. 2009; 33[4]:718-38.