A REVOLUTIONARY TREATMENT IN THE FIGHT AGAINST CKD-RELATED ANEMIA

  • A first of its kind in veterinary medicine, Varenzin-CA1 stimulates a cat’s body to create its own erythropoietin (EPO)*


  • Reasonable expectation of efficacy with minimal side effects¹


  • Approved for convenient at-home treatment; no in-clinic injections needed


  • No costly and inconvenient extra label use of erythropoietin stimulating agents (ESAs)


*Versus administering with a human EPO product

How VARENZIN-CA1 works

Anemia is caused by several factors related to kidney disease, primarily a reduction of erythropoietin (EPO), a hormone released from the kidneys that signals bone marrow to make red blood cells.2

Developed exclusively for cats, Varenzin-CA1 features a mode of action that induces the genetic transcription of EPO, increasing both EPO and red blood cell production in a cat’s body.1

Learn more about how Varenzin Works

BREAKTHROUGH INNOVATION MEETS AT-HOME CONVENIENCE

Varenzin-CA1 is a flavored, orally administered liquid given once daily that’s convenient and simple to dose.

  • Sealed prescription bottle filled with liquid and arrows indicating to shake before opening.
    Step 1

    Shake well before use. Remove screw cap.

  • Open prescription bottle with liquid inside sits on a surface as a syringe is lowered into it.
    Step 2

    Place the enclosed syringe nozzle firmly into the opening of the bottle.

  • Open prescription bottle with liquid in it has been turned upside down as a syringe draws out medicine.
    Step 3

    Turn the bottle upside down and withdraw necessary volume. Turn the bottle upright before removing syringe.

  • A syringe with medicine in it is being dispensed into a cat’s mouth.
    Step 4

    Administer directly into the cat's mouth.

VARENZIN-CA1 DOSING INFORMATION

EMPOWERED WITH EFFICACY

In a series of multicenter studies,1 Varenzin-CA1 was shown to have a reasonable expectation of efficacy managing anemia in CKD cats.

PERCENTAGE OF CATS WITH INCREASED HEMATOCRIT**

  • STUDY DAY 28


  • STUDY DAY 56


  • STUDY DAY 84


**Relative increase in HCT of >25% above baseline or an absolute increase in HCT of >=4% above baseline

Field effectiveness and safety study, effectiveness phase

††Field effectiveness and safety study, continuation phase

PROVEN SAFETY

The safety of Varenzin-CA1 was established in laboratory studies and field safety and effectiveness studies. There were minimal side effects with vomiting being the most frequently reported adverse effect.1

Varenzin™-CA1 (molidustat oral suspension) Resources

Varenzin Product Detailer

Varenzin™-CA1 (molidustat oral suspension) FAQs

Indication

Varenzin-CA1 is indicated for the control of nonregenerative anemia associated with chronic kidney disease (CKD) in cats.

Important Safety Information

For oral use in cats only. Keep this drug, including used syringes, out of reach of children.  Wash hands immediately after use.  In case of accidental ingestion, seek medical advice immediately.  Women who are pregnant or may become pregnant should administer the product with caution. Varenzin-CA1 should not be administered to cats that are pregnant, lactating or intended for breeding or to cats with known hypersensitivity to molidustat. Use with caution in cats with a history of seizures and in cats predisposed to thromboembolic disease. Hematocrit (HCT) or packed cell volume (PCV) levels should be monitored regularly as polycythemia may result from use of Varenzin-CA1. Varenzin-CA1 has not been evaluated in cats less than 1 year of age.  The most common adverse reactions included vomiting, increases in systolic blood pressure and mild transient increase in serum potassium.  Click here for full prescribing information.