The CA1 in Credelio Quattro/Credelio Quattro-CA1 stands for ‘Conditionally Approved’ by FDA. It means Credelio Quattro-CA1 is conditionally approved for the treatment of New World screwworm larvae infestations in dogs pending a full demonstration of effectiveness.

Credelio Quattro/Credelio Quattro-CA1 contains four active ingredients designed to deliver comprehensive efficacy in parasite coverage:

Lotilaner is a fast-acting parasiticide used to control ticks and fleas in dogs. It’s a member of the isoxazoline class of parasiticides that controls these pests by targeting their nervous system.

Moxidectin, a highly lipophilic macrocyclic lactone, targets glutamate-gated ion channels of invertebrates and filarial nematodes. This lipophilicity helps it have a high tissue distribution and long elimination half-life, resulting in the muscle paralysis and death of heartworms in the L3 and L4 stage – ultimately preventing heartworm disease.⁴

Praziquantel is an effective treatment for 3 species of tapeworms.^{^} Pyrantel pamoate is an established treatment for hookworms and roundworms and starts working in a matter of hours. It’s a depolarizing neuromuscular blocking agent, causing paralysis, which forces the worm to lose its grip on the intestinal wall and then pass through the dog.

^{^}Dipylidium caninum, Taenia pisiformis and Echinococcus granulosus

Only Credelio Quattro/Credelio Quattro-CA1 offers the broadest^† parasite coverage available in an isoxazoline endectocide targeting 7 types of parasites^§ in a flavored chewable tablet. Lotilaner, the active ingredient in Credelio Quattro, is proven to kill multiple species of ticks^* faster^** than sarolaner in Simparica Trio and afoxolaner in NexGard and NexGard Plus.^1,2 Credelio Quattro/Credelio Quattro-CA1 kills adult fleas, treats and prevents flea infestations, prevents heartworm disease, treats New World screwworm larvae infestations, and treats and controls infections of three intestinal worms with zoonotic risk – roundworms, hookworms and tapeworms.^§ This one-of-a-kind coverage comes in a tasty, easy-to-administer chewable tablet approved for use in dogs and puppies as young as 8 weeks weighing 3.3 pounds or more.³

^†Based on label comparison of the number of parasite types covered in an isoxazoline endectocide

^§Credelio Quattro protects dogs against ticks, fleas, heartworm disease, roundworms, hookworms, and tapeworms. Credelio Quattro-CA1 is conditionally approved for the treatment of New World screwworm larvae infestations in dogs pending a full demonstration of effectiveness. 

^*I. scapularis and A. americanum

^**Based on the time to statistical significance vs. control in two separate head-to-head studies. 

No. Credelio Quattro/Credelio Quattro-CA1 is only approved for use in dogs. However, Credelio® CAT (lotilaner) contains lotilaner, one of the active ingredients used in Credelio Quattro/Credelio Quattro-CA1, which provides fast-acting protection from ticks, kills adult fleas, and treats and prevents flea infestations.

Credelio Quattro/Credelio Quattro-CA1 has been demonstrated safe for dogs as young as 8 weeks old and weighing as little as 3.3 lbs.

If a dose is missed, a new dose should be given immediately. If vomiting occurs within an hour after administration, readminister a new dose. Then, continue with the prescribed monthly dosing schedule.

Credelio Quattro should be administered once a month, every month, to dogs and puppies 8 weeks of age and older and 3.3 pounds or greater.

Credelio Quattro-CA1 should be administered once to dogs and pupppies 8 weeks of age and older and 3.3 pounds or greater.

A complete, weight-based dosing table is available under the dosing and administration portion of this page.

Yes. For full efficacy against ticks and fleas, instruct pet owners to always give their dog Credelio Quattro/Credelio Quattro-CA1 with food or within 30 minutes of a meal. The presence of food ensures that peak blood levels and exposures of lotilaner are achieved, which is necessary for initial and ongoing efficacy.

Splitting of Credelio Quattro/Credelio Quattro-CA1 tablets is not recommended.

Content uniformity of whole and half tablets has not been established. Therefore, tablets are not scored and splitting of tablets is not advisable. A variety of tablet sizes have been developed to allow for accurate dosing according to a dog’s weight. 

Credelio Quattro/Credelio Quattro-CA1 comes in a tasty beef-flavored chewable tablet that's meat allergen-free.³

No stability testing has been performed on tablets once they have been removed from the blister pack. We do not recommend taking the tablets out of the blister pack for storage in another container. Credelio Quattro/Credelio Quattro-CA1 tablets should only be taken out of the blister pack at the time of dosing.

In clinical trials, Credelio Quattro/Credelio Quattro-CA1:

-Was 100% effective against heartworm disease in dogs from the first dose.

-Started killing fleas within 4 hours and achieved >99% efficacy in just 8 hours.⁵

-Starts to kill ticks^* in just 4 hours.

-≥ 97% effective against hookworms, and >= 99% efficacy in reduction of A. caninum fecal egg counts.

-Just 1 dose provides 100% protection from 3 species of tapeworms.^{^}

^*Ixodes ricinis

^{^}Dipylidium caninum, Taenia pisiformis and Echinococcus granulosus

Yes, Credelio Quattro/Credelio Quattro-CA1 can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD) by treating the underlying flea infestation.