Content uniformity of whole and half tablets has not been established. Therefore, Credelio tablets are not scored and splitting of Credelio tablets is not recommended. A variety of tablet sizes have been developed to allow for accurate dosing according to a dog’s weight. 

Yes, Credelio chewable tablets are formulated to provide a minimum dosage of 9 mg/lb of lotilaner. For dogs weighing greater than 100 lbs, the appropriate combination of tablets can be prescribed to achieve the desired dose for a concentration 9 mg/lb.   

Due to reduced drug bioavailability in the fasted state, Credelio must be administered with a meal or within 30 minutes of feeding to achieve full efficacy. 

Puppies should be weighed each month and dosed according to the dosing table based on their weight at the time of administration. 

Isoxazolines are chiral molecules with two stereoisomers that are exact mirror images of each other in a 50/50 ratio within the racemic mixture. For lotilaner, one of the enantiomers is active against parasites, the mirror image is inactive. Additional purification steps are taken during the manufacture of the lotilaner in Credelio to remove the inactive form. 

Since the inactive portion has been removed, the patient does not need to metabolize the inactive enantiomer and the tablets are smaller. 

Credelio tablets are made with meat flavoring containing pork liver and soy but no actual beef.⁵  Tablets also contain barley, wheat, and lactose.⁵   

Credelio has a 3-year shelf life from the date of manufacture.  

Yes, Credelio can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD) due to flea infestation. 

Lotilaner kills existing and newly emerged flea infestations on dogs before the female flea can lay eggs. In Credelio, lotilaner has shown a sustained speed-of-kill of greater than 99% within 8 hours and 100% within 12 hours throughout the month.³  

As adult fleas cannot begin laying eggs until 24 to 36 hours after taking their first blood meal, the product breaks the flea life cycle and prevents environmental flea contamination in areas to which the dog has access. 

Treatment should be administered monthly. If a dose is missed, administer Credelio with food and resume a monthly dosing schedule from that date on. 

The safe use of Credelio in breeding, pregnant or lactating dogs has not been evaluated.

While Credelio cannot be used in cats, Credelio® CAT (lotilaner) is available with a lotilaner minimum dosage of 2.7 mg/lb.