Trifexis (Spinosad + milbemycin oxime)

Trifexis® (spinosad + milbemycin oxime)

Trifexis is a monthly, beef-flavored tablet that kills fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm and whipworm infections. Intended for use in dogs and puppies 8 weeks and older who weigh 5 lbs or more.

Protect with Trifexis

  • Fleas_1 Icon

    Kills fleas and prevents infestations

  •  Worms Icon

    Prevents heartworm disease

  •  Parasites Icon

    Treats and controls adult hookworm, roundworm, whipworm; prevents heartworm disease; prevents and treats flea infestations

Trifexis Dosing and Administration

Product name - Trifexis (Magenta Box)
Weight bands -

5 – 10 lbs

Product name - Trifexis (Orange Box)
Weight bands -

10.1 – 20 lbs

Product name - Trifexis (Green Box)
Weight bands -

20.1 – 40 lbs

Product name - Trifexis (Blue Box)
Weight bands -

40.1 – 60 lbs

Product name - Trifexis (Brown Box)
Weight bands -

60.1 – 120 lbs

Product name - Administer the appropriate combination of tablets
Weight bands -

> 120 lbs

Trifexis® (spinosad + milbemycin oxime) Resources

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Stock Trifexis at your clinic

Trifexis offers your patients 3-in-1 protection against fleas, heartworm disease, and intestinal parasites, including hookworm, roundworm and whipworm. 

Trifexis® (spinosad + milbemycin oxime)


Trifexis® is indicated for the prevention of heartworm disease (Dirofilaria immitis). Trifexis® kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.

Important Safety Information (ISI)

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis®. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis®, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis® in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, depression/lethargy, pruritus, anorexia, and diarrhea. To ensure heartworm prevention, dogs should be observed for one hour after administration. If vomiting occurs within one hour of administration, redose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For full prescribing information see Trifexis® package insert.