Comfortis® (Spinosad) for dogs and cats

A fast, safe and effective flea treatment for the infestations on dogs and cats. Comfortis kills fleas before they lay eggs and keeps killing fleas for a full month with each dose.

Protect Your Pet with Comfortis

  • Begins killing fleas in as little as 30 minutes

  • Improves signs of flea allergy dermatitis (FAD) through its rapid action on fleas

  • 30-day protection, even if your pet swims, bathes or grooms frequently

Dosing for Dogs

Product Name - Comfortis (magenta)
Weight Bands -

5 – 10 lbs

Product Name - Comfortis (orange)
Weight Bands -

10.1 – 20 lbs

Product Name - Comfortis (green)
Weight Bands -

20.1 – 40 lbs

Product Name - Comfortis (blue)
Weight Bands -

40.1 – 60 lbs

Product Name - Comfortis (brown)
Weight Bands -

60.1 – 120 lbs

Product Name - Administer the appropriate combination of tablets
Weight Bands -

> 120 lbs

Dosing for Cats

Product Name - Comfortis (magenta)
Weight Bands -

4.1-6 lbs

Product Name - Comfortis (orange)
Weight Bands -

6.1 - 12 lbs

Product Name - Comfortis (green)
Weight Bands -

12.1 – 24* lbs *Cats over 24 lbs. should be administered the appropriate combination of tablets.

The Story of Spinosad

Stock Comfortis at Your Clinic

For fast, effective flea control, when only flea control is required, turn to Comfortis for 30-day control.

Comfortis® (Spinosad) 


Comfortis for dogs indications:

COMFORTIS kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis) for one month, on dogs and puppies 14 weeks of age and older and 5.0 pounds of body weight or greater.


Comfortis for dogs Important Safety Information (ISI)

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with Comfortis. Use with caution in breeding females and dogs with pre-existing epilepsy. The safe use of Comfortis in breeding males has not been evaluated. The most common adverse reactions reported were vomiting, depression/lethargy, anorexia, ataxia, diarrhea, pruritus, trembling, hypersalivation and seizures. Post approval experience continues to support the safety of Comfortis when used concurrently with heartworm preventives according to label directions. For complete directions for use and safety information read product label.


Comfortis for cats indications:

COMFORTIS kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), for one month, on cats and kittens 14 weeks of age and older and 4.1 pounds of body weight or greater.


Comfortis for cats Important Safety Information (ISI)

For cats: Use with caution with concomitant extra-label use of ivermectin. The safe use of Comfortis in breeding, pregnant, or lactating cats has not been evaluated. The most common adverse reactions reported were vomiting, lethargy, anorexia, weight loss, and diarrhea. For complete directions for use and safety information read product label.