Make More Dogs Quattro Dogs with 6 in 1 Protection
Credelio Quattro™ is the broadest* parasite protection available in an isoxazoline endectocide. Unlike other endectocides, Credelio Quattro protects against six types of parasites in one monthly flavored chewable tablet.
†Uncinaria stenocephala
*Based on label comparison of the number of parasite types covered in an isoxazoline endectocide for dogs
Why choose Credelio Quattro?
100% effective at preventing heartworm disease from the first dose.
Contains lotilaner that kills ticks§ faster¶ than sarolaner in Simparica Trio® & afoxolaner in NexGard®.1
Contains the same established dose of lotilaner found in Credelio®.
The first and only canine oral isoxazoline endectocide that covers tapeworms.
The Broadest Parasite Protection of its Kind* Covering 6 Types of Parasites Including Ticks, Fleas, Heartworms, Roundworms, Hookworms†, and Tapeworms.
*Based on label comparison of the number of parasite types covered in an isoxazoline endectocide for dogs
†Uncinaria stenocephala
§Amblyomma americanum (lone star tick)
¶Based on the time to statistical significance vs. control in a study comparing Credelio® (lotilaner)—not Credelio Quattro™, which contains lotilaner as well as moxidectin, praziquantel, and pyrantel — to the active ingredients in Simparica Trio® (sarolaner, moxidectin, and pyrantel) and NexGard® (afoxolaner).
Nearly 9 out of 10 dogs accepted Credelio Quattro
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Mode of Action for Credelio Quattro
Trusted Protection:
Credelio Quattro Protection Against Ticks and Fleas
Credelio Quattro contains extra-purified lotilaner protecting your dog against ticks & fleas.
The inactive enantiomer is removed decreasing the potential for additional side effects.2
In a study1, lotilaner was shown to inhibit the neuromuscular function of ticks§ in just 2 hours.
In flea infested homes, just 3 monthly doses of lotilaner reduced flea populations by 99.5-100%.
§Amblyomma americanum (lone star tick)
When Protecting Patients, Faster is Better
- 4 HOURS Starts killing fleas in just 4 hours
- 8 HOURS Kills 99% of fleas within just 8 hours of administration
- 24 HOURS Kills 100% of fleas 24 hours after administration and remains effective for an entire month
Speed of Kill Against A. americanum1
Time point at which each active ingredient achieved consistent superior efficacy versus untreated control group (P ≤ 0.05)
1Reif KE,Kollasch TM,Neilson JC, et al. Comparative speed of kill provided by lotilaner(Credelio™), sarolaner (Simparica Trio™), and afoxolaner (NexGard™) to control Amblyomma americanum infestations on dogs. Parasit Vectors. 2024;17(1):313.
Longer Half-Life
Lotilaner reaches peak absorption in only 2 hours and maintains high, sustained blood levels for the entire month.3,4
Easy to Pick Up, Hard to Diagnose
Tapeworm infections are common, but some can be easy to miss.
Dipylidium caninum can be diagnosed by their shedding of large, visible proglottids. Adult tapeworms range from 15-70 cm.8
Echinococcus are difficult to diagnose due to their small size and low number of body segments. E. granulosus grow to just 2-7 mm.9
A Zoonotic Risk
Tapeworms don't just threaten dogs: they can be passed from dogs to humans. CAPC recommends monthly deworming of dogs with praziquantel in areas where E. granulosus tapeworms are endemic.8,9
A single monthly dose of Credelio Quattro has been shown to be 100% efficacious against tapeworms# with its industry-established dose of praziquantel (2.28mg/lb).
#Echinococcus granulosus, Dipylidium canium, and Taenia pisiformis
Want to Learn More?
Take a deep dive into the broadest* parasite protection of its kind in a chewable tablet against six types of parasites: ticks, fleas, heartworms, roundworms, hookworms† and tapeworms.
*Based on label comparison of the number of parasite types covered in an isoxazoline endectocide for dogs
†Uncinaria stenocephala
What Threat Do Parasites Pose?
Indications for Credelio Quattro
Credelio Quattro is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (adult Unicaria stenocelphala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections.
Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick) and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater.
Important Safety Information for Credelio Quattro
Lotilaner, an ingredient in Credelio Quattro, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, ataxia, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro administration as it is not effective against adult D. immitis. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. For full prescribing information see Credelio Quattro package insert.
