10 mg/kg imidacloprid 

2.5 mg/kg moxidectin for dogs 

Moxidectin is quickly absorbed through the skin into the subcutaneous fat and the bloodstream to prevent heartworm disease, treat and control internal parasites, and treat sarcoptic mange in dogs. Imidacloprid spreads over the skin and coat to kill fleas through contact so they do not have to bite to die.

As heartworm, fleas and internal parasites can be a threat year-round, we recommend the use of Advantage Multi® monthly, year-round for your patients. 

For dogs, the recommended minimum dose is 4.5 mg/lb. (10.0 mg/kg) imidacloprid and 1.1 mg/lb. (2.5 mg/kg) moxidectin once a month by topical administration. Administer the entire contents of the Advantage Multi® for Dogs tube that correctly corresponds with the body weight of the dog.  

Advantage Multi® 9 for Dogs 

For dogs weighing 3-9 lbs. 

1 card / 6 doses per card (0.4 mL tubes) – 08891454 

Advantage Multi® 20 for Dogs 

For dogs weighing 9.1-20 lbs. 

1 card / 6 doses per card (1.0 mL tubes) – 08891462 

Advantage Multi® 55 for Dogs 

For dogs weighing 20.1-55 lbs. 

1 card / 6 doses per card (2.5 mL tubes) – 08891470 

Advantage Multi® 88 for Dogs 

For dogs weighing 55.1-88 lbs. 

1 card / 6 doses per card (4.0 mL tubes) – 08891489 

Advantage Multi® 110 for Dogs 

For dogs weighing 88.1-110 lbs. 

1 card / 6 doses per card (5.0 mL tubes) – 80560290 

Yes, you can still treat your patients with Advantage Multi® with the appropriate combination of tubes to meet the dog’s proper weight specifications. 

Advantage Multi® for Dogs prevents heartworm disease in dogs after a swim or bath, 90 minutes respectively, after application.¹  

Product Label

1. Freedom of Information Summary: NADA 141-251.  

CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian.   

WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information.)  

CONTRAINDICATIONS: Do not use this product on cats.  

We recommend bathing dogs BEFORE applying the product. The product can be applied once the dog is towel dried. Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi® for Dogs in the prevention of heartworm disease. Shampooing or water immersion 4 days after treatment does not reduce the effectiveness of Advantage Multi® for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas. Please use a pet shampoo that is soap-free.  

Product Label 

CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian.   

WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information.)  

Do not apply to irritated skin.

1. Remove one dose applicator tube from the package.  

2. While holding the tube in an upright position, remove the cap from the tube.  

3. Turn the cap over and push the other end of the cap onto the tip of the tube.  

4. Twist the cap to break the seal and then remove cap from the tube.  

5. The dog should be standing for application. Part the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Do not apply an amount of solution at any one location that could run off the side of the dog.

Do not let this product get in the dog's mouth or eyes. Do not allow the dog to lick any of the application sites for 30 minutes  

Product Label  

CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian.   

WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information.)  

CONTRAINDICATIONS: Do not use this product on cats.

Advantage Multi® for Dogs is for use on puppies at least 7 weeks old and weighing at least 3 pounds.  

Product Label   

CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian.  

WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information.)  

CONTRAINDICATIONS: Do not use this product on cats.   

Treatment should be administered monthly. If your clients forget or miss a dose, they can treat their dogs immediately.* 

*After a single dose, if your clients forget and go more than 30 days in between treatments, just treat immediately and resume the monthly schedule.  

Please refer to the Product Label for more information.

CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian.  

WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information.)  

CONTRAINDICATIONS: Do not use this product on cats.